Dihexa
Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide)
Last updated: March 2026
Sequence
6 amino acids (modified)
Origin
Synthetic angiotensin IV analogue
Research Dose
Research protocols use very low doses due to extreme potency: 10-20mg subcutaneous or oral. Animal studies used 2mg/kg intranasal.
Category
Nootropic
How It Works
Dihexa is a synthetic peptide derived from angiotensin IV that acts as a hepatocyte growth factor (HGF) receptor agonist. It promotes synaptogenesis (new synapse formation) and neuronal connectivity at extraordinarily low concentrations (picomolar range). Researchers at Washington State University found it 10 million times more potent than BDNF in promoting new neural connections.
Key Benefits
Studied for cognitive enhancement
May promote synaptogenesis
Researched for neurodegenerative conditions
Extremely potent at picomolar concentrations
Research Highlights
10 million times more potent than BDNF for synaptogenesis
Acts via HGF/c-Met receptor system
Improved cognitive function in animal models of dementia
Active at picomolar concentrations (extremely potent)
Crosses blood-brain barrier after subcutaneous injection
Available Forms
- Lyophilized powder for injection
- Oral capsules (research)
Legal Status
Dihexa is available for research purposes. Not FDA-approved. Not a controlled substance. Limited human safety data available.
Research & Education Only — The information on this page is for research and educational purposes only. It does not constitute medical advice. Consult a qualified healthcare professional before making any decisions.