MOTS-c
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c)
Last updated: March 2026
Sequence
16 amino acids
Origin
Mitochondrial-derived peptide
Research Dose
Research protocols typically use 5-10mg subcutaneous, 3-5 times per week. Dosing is based on animal studies and early human research.
Category
Anti-Aging
How It Works
MOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA gene. It acts as a metabolic regulator and exercise mimetic by activating AMPK pathways, improving glucose uptake, and enhancing fatty acid oxidation. Naturally released during exercise, MOTS-c levels decline with age, making it a target for anti-aging research.
Key Benefits
Mitochondrial-derived exercise mimetic
May improve metabolic function
Studied for insulin sensitivity
Potential longevity applications
Research Highlights
First mitochondrial-derived peptide shown to regulate nuclear gene expression
Activates AMPK (cellular energy sensor) pathway
Improves insulin sensitivity in animal models
Levels decline with age and increase with exercise
Research suggests it may improve physical performance and metabolic health
Available Forms
- Lyophilized powder for injection
Legal Status
MOTS-c is available for research purposes. Not FDA-approved. Not a controlled substance.
Research & Education Only — The information on this page is for research and educational purposes only. It does not constitute medical advice. Consult a qualified healthcare professional before making any decisions.